Blood coagulation and tissue formation

Initial blood contact leads to fibrin network formation

The blood coagulum can be considered as the first provisional tissue that forms around an implant. The fibrin matrix and activated thrombocytes can be considered as key players within the coagulum by providing a scaffold for the invasion of osteogenic cells.

The composition, structure and organization of the forming blood clot differ significantly between INICELL® and unconditioned substrates.

Both the activation of blood coagulation and the number of activated thrombocytes were increased on INICELL® substrates.1

1 Milleret, et al., Eur Cell Master. 2012; 15, 21: 430-44.