Scientific data on osseointegration

In vitro and in vivo studies.

In vitro: the performance and benefits of INICELL® have been investigated in a number of studies.

In vivo: three different animal models were used to compare the unconditioned reference implants with the conditioned INICELL® implants of the same type in the following:

  • pelvis of sheep1
  • mini-pig mandible2
  • beagle dog mandible3

These results confirm in-vitro and animal studies from the published literature which highlight the advantages of superhydrophilic, microrough surfaces.4-7

The picture shows the bone-to-implant interface in the early healing phase of the mini-pig model (left with unconditioned Thommen surface and right with INICELL®).

1 Ferguson S.J., et al., Poster presented at the 16th Annual Scientific Meeting of the European Association for Osseointegration (EAO), Barcelona, October 2007.
2 Stadlinger B., et. al., J Clin Periodontol 2009; 36: 882–891 and data presented at the 17th Annual Scientific Meeting of the European Association for Osseointegration (EAO), Warsaw, September 2008.
3 Calvo-Guirado J.-L., et al., Clin. Oral Impl. Res. 2010; 21 308–315.
4 Heberer S., et al. Clin. Oral Impl. Res. 2011; 22: 546–551.
5 Lang N., et al. Clin. Oral Impl. Res. 2011;22: 349–356.
6 Mardas N. Clin. Oral Impl. Res. 2011;22: 406–415.
7 Rupp F., et al. Int J Oral Maxillofac Implants. 2011; 26,6: 1256-1266.