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Benefits at a Glance

  • Safety from the start due to low early failure rates (Le Gac 2015)
  • Rapid osseointegration in the early healing phase (Calvo 2010)
  • A safe and predictable treatment option after just three weeks (Hicklin 2015, Hinkle 2014)
  • Shortened healing time also in patients with reduced bone quality (Grades 3 and 4) (Held 2014)

INICELL®

Evolution in surface technology

Due to slight changes in surface chemistry, the implant surface is transferred from a hydrophobic state to a superhydrophilic surface condition (INICELL®).

These properties of INICELL® promote spontaneous and complete wetting of the implant with physiological fluids, especially blood (Tugulu 2010).

This accelerates the wound healing cascade (Milleret 2011, Burkhardt 2016, Burkhardt 2017), which is reflected in higher bone to implant contact and higher implant stability in the early healing phase. From a clinical point of view, this results in a low early failure rate (0.5%, Le Gac 2015) and a safe and predictable treatment option after three weeks (Hicklin 2015, Hinkle 2014). A shortened healing time can also be achieved in patients with reduced bone quality (Grades 3 and 4) (Held 2014).

Designed for function

Simple use. Instant application.

1. Push in the cartridge
2. Shake the applicator five times
3. Place the implant

The APLIQUIQ® container contains the conditioning agent, implant and healing cap. For outstanding product development and design, Thommen Medical AG has been honored with the distinguished reddot design product award 2011. APLIQUIQ® was selected by the reddot committee based on the product’s practical design, useful functionality and innovative technology.

 

Surface Topography

The gold standard for osseointegration

Many consider the sandblasted, thermal acid-etched microrough surface to be the gold standard for implant surface modification.

The advantage for implants that feature a microrough surface is that they establish excellent functional and structural connections between the bone and the implant surface, leading to higher intrinsic implant stability (Buser 1999).

Specifically, the microrough surface enhances the interlocking of the implant surface with bone and has been shown to promote the differentiation of osteogenic cells in-vitro (Boyan 2001).

Scanning electron microscopic images of the microrough sandblasted and thermal acid-etched surface of Thommen implants with increasing magnification.

 

Optimized Osseointegration

Fluorescence microscopic picture of the protein film on model substrates five minutes after primary contact with protein solution.

The quantity, composition, homogenity and functionality of the protein film deposited on the implant surface directly influences the healing and osseointegration processes to follow. 

Flyer - INICELL® 

Literature

Boyan B et al. Titanium in medicine. Brunette DM et al. (eds.) Springer, 2001: 562-79.

Brodbeck W. G., et al., J. M. Proc. Natl. Acad. Sci. USA 2002; 99, 10: 287-292.

Burkhardt M, Gerber I, Moshfegh C, Lucas M, Waser J, Emmert M Y, Hoerstrup S P, Schlottig F, Vogel V. Biomat. Sci. 2017, doi: 10.1039/c7bm00276a.

Burkhardt M A, Waser J, Milleret V, Gerber I, Emmert M Y, Foolen J, Hoerstrup S P, Schlottig F, Vogel V. Nature, Scientific Reports, 6:21071.

Buser D, Nydegger T, Oxland T, Cochran DL, Schenk RK, Hirt HP, Snétivy D, Nolte LP. J Biomed Mater Res. 1999; 45(2): 75-83.

Calvo-Guirado JL, Ortiz-Ruiz AJ, Negri B, López-Marí L, Rodriguez-Barba C, Schlottig F. Clinical Oral Implants Research 21, no. 3 (2010): 308-15.

Derks J, Håkansson J, WennströmJL, Tomasi C, Larsson M, Berglundh T. JDR March 94 no. 3 suppl (2015): 44-51.

van Eekeren P, Tahmaseb A, Wismeijer D. Clinical Oral Implants Research 0, (2015): 1-6.

Held U, Rohner D, Rothamel D. Head and Face Medicine 9, no. 37 (2013): 1-9.

Hinkle RM, Rimer SR, Morgan MH, Zeman P. Journal of Oral and Maxillofacial Surgery 72 no. 8 (2014): 1495-1502.

Le Gac O, Grunder U. Dentistry Journal, no 3 (2015): 15-23.

Milleret V, Tugulu S, Schlottig F, Hall H. European Cells and Materials 21 (2011): 430-44.

Stadlinger B, Lode AT, Eckelt U, Range U, Schlottig F, Hefti T, Mai R. Journal of Clinical Periodontology 36, no. 10 (2009): 882-891.

Stadlinger B, Ferguson SJ, Eckelt U, Mai R, Lode AT, Loukota R, Schlottig F. The British Journal of Oral & Maxillofacial Surgery 50, no. 1 (2012): 74-9.

Tugulu S, Löwe K, Scharnweber D, Schlottig F. Journal of Materials Science Materials in Medicine 21, no.10 (2010): 2751-2763.

Tugulu S, Hall H, Schlottig F. Clinical Oral Implants Research 20, no. 9 (2009): 1024-25 (poster no. 376).

Vasak C, Busenlechner D, Schwarze UY, Leitner HF, Munoz Guzon F, Hefti T, Schlottig F, Gruber R. Clinical Oral Implants Reserach 25, no. 12 (2014) 1378-85.

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