Improvement in the initial ISQ through use of a modified surgical technique
Through Use of a Modified Surgical Technique
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Flyer - INICELL®
Many consider the sandblasted, thermal acid-etched microrough surface to be the gold standard for implant surface modification.
The advantage for implants that feature a microrough surface is that they establish excellent functional and structural connections between the bone and the implant surface, leading to higher intrinsic implant stability.¹
Specifically, the microrough surface enhances the interlocking of the implant surface with bone and has been shown to promote the differentiation of osteogenic cells in-vitro.²
Surface energy and hydrophilicity play a crucial role in the primary interaction of an implant with its physiological environment.¹ This interaction begins immediately upon the first blood contact, in the form of rapid adsorption of a film of plasma proteins. INICELL® (right) exhibits a complete and homogenous protein film, indicating full contact with the physiological protein solution. The unconditioned surface (left) shows a nonhomgenous protein film. The result suggests advantageous primary contact and protein adsorption for INICELL®.²
Fluorescence microscopic picture of the protein film on model substrates five minutes after primary contact with protein solution.
The quantity, composition, homogenity and functionality of the protein film deposited on the implant surface directly influences the healing and osseointegration processes to follow.
1 Brodbeck W. G., et al., J. M. Proc. Natl. Acad. Sci. USA 2002; 99, 10: 287-292.
By slightly changing the surface chemistry, it is possible to increase surface energy. When surface energy increases, a superhydrophilic surface is created and wettability is improved. Thereby, a hydrophobic surface is changed into a superhydrophilic surface (INICELL®).¹
Download document¹ Tugulu S., et al., J Mater Sci Mater med. 2010; 21, 10: 2751-63.
Designed for function
APLIQUIQ® is the fast and effective chairside conditioning system used to produce the superhydrophilic INICELL® surface.
The APLIQUIQ® container contains the conditioning agent, implant and healing cap. For outstanding product development and design, Thommen Medical AG has been honored with the distinguished reddot design product award 2011. APLIQUIQ® was selected by the reddot committee based on the product’s practical design, useful functionality and innovative technology..
These results confirm in-vitro and animal studies from the published literature which highlight the advantages of superhydrophilic, microrough surfaces. ⁴ ⁵ ⁶ ⁷
The picture shows the bone-to-implant interface in the early healing phase of the mini-pig model (left with unconditioned Thommen surface and right with INICELL®).
1 Ferguson S.J., et al., Poster presented at the 16th Annual Scientific Meeting of the European Association for Osseointegration (EAO), Barcelona, October 2007.
2 Stadlinger B., et. al., J Clin Periodontol 2009; 36: 882–891 and data presented at the 17th Annual Scientific Meeting of the European Association for Osseointegration (EAO), Warsaw, September 2008.
3 Calvo-Guirado J.-L., et al., Clin. Oral Impl. Res. 2010; 21 308–315.
4 Heberer S., et al. Clin. Oral Impl. Res. 2011; 22: 546–551.
5 Lang N., et al. Clin. Oral Impl. Res. 2011;22: 349–356.
6 Mardas N. Clin. Oral Impl. Res. 2011;22: 406–415.
7 Rupp F., et al. Int J Oral Maxillofac Implants. 2011; 26,6: 1256-1266.