Building the Implant Practice
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The INICELL® implant surface for rapid osseointegration. The unique conditioning process creates a superhydrophilic implant surface – a prerequisite for optimal wettability and rapid initiation of new bone formation.
"Best prerequisites for optimal tissue integration."
Dr. K. Meyenberg, Zurich, CH
Slight changes in surface chemistry change the implant surface from a hydrophobic to a superhydrophilic surface state (INICELL®).
These properties of INICELL® favor a spontaneous and complete wetting of the implant with physiological fluids, especially with blood (Tugulu 2010).
This accelerates the wound healing cascade (Milleret 2011, Burkhardt 2016, Burkhardt 2017), resulting in higher bone-to-implant contact and greater implant stability in the early healing phase.
From a clinical perspective, this results in a low early loss rate (0.5%, Le Gac 2015) and a safe and predictable treatment option after three weeks (Hicklin 2015, Hinkle 2014).
A shorter healing time can also be achieved in patients with reduced bone quality (Class 3 and 4) (Held 2014).
The APLIQUIQ® container contains the conditioning agent, implant and healing cap. For outstanding product development and design, Thommen Medical AG has been honored with the distinguished reddot design product award 2011. APLIQUIQ® was selected by the reddot committee based on the product’s practical design, useful functionality and innovative technology.
Many consider the sandblasted, thermal acid-etched microrough Surface to be the Gold Standard for Implant Surface modification.
The advantage for implants that feature a microrough surface is that they establish excellent functional and structural connections between the bone and the implant surface, leading to higher intrinsic implant stability (Buser 1999).
Specifically, the microrough surface enhances the interlocking of the implant surface with bone and has been shown to promote the differentiation of osteogenic cells in-vitro (Boyan 2001).
Scanning electron microscopic images of the microrough sandblasted and thermal acid-etched surface of Thommen implants with increasing magnification.
Fluorescence microscopic picture of the protein film on model substrates five minutes after primary contact with protein solution.
The quantity, composition, homogenity and functionality of the protein film deposited on the implant surface directly influences the healing and osseointegration processes to follow.
Boyan B et al. Titanium in medicine. Brunette DM et al. (eds.) Springer, 2001: 562-79.
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Burkhardt M, Gerber I, Moshfegh C, Lucas M, Waser J, Emmert M Y, Hoerstrup S P, Schlottig F, Vogel V. Biomat. Sci. 2017, doi: 10.1039/c7bm00276a.
Burkhardt M A, Waser J, Milleret V, Gerber I, Emmert M Y, Foolen J, Hoerstrup S P, Schlottig F, Vogel V. Nature, Scientific Reports, 6:21071.
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Calvo-Guirado JL, Ortiz-Ruiz AJ, Negri B, López-Marí L, Rodriguez-Barba C, Schlottig F. Clinical Oral Implants Research 21, no. 3 (2010): 308-15.
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van Eekeren P, Tahmaseb A, Wismeijer D. Clinical Oral Implants Research 0, (2015): 1-6.
Held U, Rohner D, Rothamel D. Head and Face Medicine 9, no. 37 (2013): 1-9.
Hinkle RM, Rimer SR, Morgan MH, Zeman P. Journal of Oral and Maxillofacial Surgery 72 no. 8 (2014): 1495-1502.
Le Gac O, Grunder U. Dentistry Journal, no 3 (2015): 15-23.
Milleret V, Tugulu S, Schlottig F, Hall H. European Cells and Materials 21 (2011): 430-44.
Stadlinger B, Lode AT, Eckelt U, Range U, Schlottig F, Hefti T, Mai R. Journal of Clinical Periodontology 36, no. 10 (2009): 882-891.
Stadlinger B, Ferguson SJ, Eckelt U, Mai R, Lode AT, Loukota R, Schlottig F. The British Journal of Oral & Maxillofacial Surgery 50, no. 1 (2012): 74-9.
Tugulu S, Löwe K, Scharnweber D, Schlottig F. Journal of Materials Science Materials in Medicine 21, no.10 (2010): 2751-2763.
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Vasak C, Busenlechner D, Schwarze UY, Leitner HF, Munoz Guzon F, Hefti T, Schlottig F, Gruber R. Clinical Oral Implants Reserach 25, no. 12 (2014) 1378-85.